Organically modified clay supported chitosan/hydroxyapatite-zinc oxide nanocomposites with enhanced mechanical and biological properties for the application in bone tissue engineering

摘要

Highlights?Development of biomimetic OMMT supported chitosan/hydroxyapatite-zinc oxide nanocomposites (ZnCMH I-III).?Strong antibacterial properties against Gram-positive and Gram-negative bacterial strains were observed for ZnCMH I-III.?Cytocompatibility with MG-63 cells were established for ZnCMH I-III.?pH and blood compatibility study revealed that ZnCMH I-III should be compatible with human body.?Addition of 5wt% of OMMT into CTS/HAP-ZnO (ZnCMH I) gives the best mechanical properties and water absorption capacity.AbstractThe objective of this study is to design biomimetic organically modified montmorillonite clay (OMMT) supported chitosan/hydroxyapatite-zinc oxide (CTS/HAP-ZnO) nanocomposites (ZnCMH I-III) with improved mechanical and biological properties compared to previously reported CTS