Synthesis and Structural Elucidation of Novel 2,4-Disubstituted 1,3-OxazoIe Analogues for Pharmacological Properties

摘要

A series of novel 2,4-disubstituted 1,3-oxazole analogues (3a-i) has been designed and synthesized between l-[3,5-bis-(trifluoromethyl)-phenyl]-2-bromoethan-l-one and substituted amides by microwave assisted method. 2,4-Disubstituted 1,3-oxazole analogues obtained were at excellent yields and purity of the compound was ascertained by HPLC. The chemical structure of these compounds was elucidated by spectrometric (FT-IR, NMR and LCMS) and elemental analysis. It was observed that, microwave method influenced the better yield and reduction in reaction time when compared to conventional reflux method.