Chemical Composition and Anticancer Activity of Macaranga hosei Leaves

摘要

The anticancer activity of methanolic extract and ethyl acetate fraction of Macaranga hosei leaves against HeLa cell lines were evaluated by [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay. Both extracts displayed anticancer activity with IC_(50) values of 36.18 and 7.01 uM, respectively, which can be suggested that M. hosei is a great potential source of anticancer agents. In addition, two isoprenylated flavanones, 4'-0-methyl-8-isoprenyl eriodictyol (1) and 6-isoprenyl eriodictyol (2) have been isolated from ethyl acetate fraction. The structures of both compounds have been elucidated based on their spectroscopic data, including 1D and 2D NMR spectra.