DNA/BSA Binding, Molecular Docking, Nuclease Activity and Cytotoxicity Studies of Hydrazide Based Schiff Base Complexes

摘要

Anew series of hydrazide based Schiff base metal Cu(II)/Zn(H) complexes of the type [Cu(Ll-L4)2] and [Zn(Ll-L4)2] has been synthesized and characterized by various analytical and spectral techniques. The proposed geometry of metal complexes, square planar for Cu2+ ion and tetrahedral for Zn2+ ion was confirmed by the spectral and analytical results. DNA interaction with metal complexes was explored by spectral and molecular docking analysis. The results obtained indicates that Cu(H)/Zn(II) complexes interaction with DNA via an intercalative binding mode and its respective intrinsic binding constant (Kb) was found in the order of7>8>5>6>3>4>l>2. Further, similar interactions of these metal complexes with BSA were found in the same order of binding constant. Furthermore, the complexes showed moderate cleavage ability with pUC19 DNA. Cytotoxicity studies confirmed the biological importance of the Schiff base complexes.