Synthesis and Characterization of 2-Pyrazoline Derivatives and their in silico and in vitro Studies on Antimicrobial and Anticancer Activities

摘要

The new series of 1-(4,5-dihydro-5-phenyl-3-diphenylpyrazol-l-yl)butan-l-one derivatives were synthesized by cyclization method using biphenyl chalcone with n-butyric acid and hydrazine hydrate. The synthesized l-(4,5-dihydro-5-phenyl-3-diphenylpyrazol-l-yl)butan-l-one derivatives chemical strucmres were confirmed from spectral data such as FT-IR, 'H and 13C NMR. 2-Pyrazoline derivatives were docked with bacterial (1UAG) and breast cancer (10QA) protein. Based on high binding affinity score, the best compound was subjected to in vitro anticancer activity by MTT assay. Also, antimicrobial activity were studied for synthesized 2-pyrazoline derivatives.