Drug-Loaded Carbon Nanoparticle Suspension Injection: Drug Selection, Releasing Behavior, In Vitro Cytotoxicity and In Vivo Lymph Node Targeting

摘要

In this study, drug-loaded carbon nanoparticle suspension as theranostic carrier was prepared for lymph node targeting delivery. Five model anti-cancer drugs were chosen to evaluate the drug selection, drug loading and releasing performance of carbon nanoparticle suspension. The relative recovery, precision, stability and limited detection range were studied in details. We found that the CNSI selectively adsorbed DOX and EPI and hardly adsorbed PTX, CDDP and 5-FU. The isothermal curves of CNSI adsorption to DOX and EPI are all fitted well with the Freundlich model. The adsorption process is not monolayer adsorption. By in vivo topical administration of DOX-loaded CNSI and EPI-loaded CNSI, we found that the drug-loaded CNSI were not only maintained its lymph node staining properties but also targeted delivery the drugs to the lymph node. The results demonstrated that the CNSI is not only used to vital staining of lymph vessels and lymph nodes but also can be used as drug delivery carrier. CNSI is a promising theranostic carrier for DOX or EPI delivery in cancer therapy.