Influence of Process Parameters on the Content of Biomimetic Calcium Phosphate Coating on Titanium: A Taguchi Analysis

摘要

In this study, a statistical design of experimental methodology based on Taguchi orthogonal design has been used to study the effect of various processing parameters on the amount of calcium phosphate coating produced by such technique. Seven control factors with three levels each including sodium hydroxide concentration, pretreatment temperature, pretreatment time, cleaning method, coating time, coating temperature and surface area to solution volume ratio were studied. X-ray diffraction revealed that all the coatings consisted of the mixture of octacalcium phosphate (OCP) and hydroxyapatite (HA) and the presence of each phase depended on the process conditions used. Various content and size (～1-100 μm) of isolated spheroid particles with nanosized plate-like morphology deposited on the titanium surface or a continuous layer of plate-like nanocrystals having the plate thickness in the range of ～100-300 nm and the plate width in the range of 3-8 μm were formed depending on the process conditions employed. The optimum condition of using sodium hydroxide concentration of 1 M, pretreatment temperature of 70℃, pretreatment time of 24 h, cleaning by ultrasonic, coating time of 6 h, coating temperature of 50℃ and surface area to solution volume ratio of 32.74 for producing the greatest amount of the coating formed on the titanium surface was predicted and validated. In addition, coating temperature was found to be the dominant factor with the greatest contribution to the coating formation while coating time and cleaning method were significant factors. Other factors had negligible effects on the coating performance.