首页> 外文期刊>Current diabetes reviews >Association of Hypothyroidism with Body Mass Index, Systolic Blood Pressure and Proteinuria in Diabetic Patients: Does treated Hypothyroidism with Thyroxine Replacement Therapy Prevent Nephropathy/Chronic Renal Disease?
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Association of Hypothyroidism with Body Mass Index, Systolic Blood Pressure and Proteinuria in Diabetic Patients: Does treated Hypothyroidism with Thyroxine Replacement Therapy Prevent Nephropathy/Chronic Renal Disease?

机译:甲状腺功能减退症与糖尿病患者的体重指数,收缩压和蛋白尿的关联:甲状腺激素替代疗法治疗的甲状腺功能减退症能预防肾病/慢性肾脏病吗?

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Untreated or sub-clinical hypothyroidism is associated with insulin resistance, obesity, adverse effects on cardiovascular system, hypertension and in turn risk of nephropathy. However, these changes are reversible with thyroxine replacement therapy (TRT). Current research studied 4235 diabetic patients, divided into two groups, those with clinical hypothyroidism /on TRT, compared to those without thyroid disease or undiagnosed. BMI, blood pressure, creatinine, urine microalbumin and spot urine protein levels were compared between these two groups. Study finding demonstrated that for hypothyroid cases, BMI was higher (32.2 ± 7.44 versus 29.4 ± 5.7; p < 0.0001), serum creatinine was on lower levels (0.75 ± 0.27 versus 1.0 ± 0.74; p = 0.001), systolic BP was on lower side (123.7 ± 15.9 versus 128.13 ± 16.8; p= 0.015); spot urine microalbumin was on lower side (52.58 ± 71.65; versus 87.77 ± 140.86; p=0.010) and spot urine protein had lower levels (25.3 ± 38.3 versus 44.28 ± 123.58; p < 0.0001). Current research also demonstrated that Pearson`s x2 and odds/protective odds for hypothyroidism (on TRT) was strongly associated with obesity (p <0.0001; odds ratio 2.28, 95% CI 1.47 to 3.56). However, they were protected from HTN (p= 0.272; protective odds ratio 1.28, 95%CI 0.824 to 1.98), nephropathy (p=0.386; protective odds 1.36, 95% CI 0.861 to 2.14) and chronic renal disease (p= 0.112; protective odds 3.42, 95% CI 0.83 to 14.13). In conclusion, TRT itself has protective effects on cardiovascular and renal system. Hence, thyroid screening is essential among diabetics to detect sub clinical or clinical hypothyroidism.
机译:未经治疗或亚临床甲状腺功能减退症与胰岛素抵抗,肥胖症,对心血管系统的不良影响,高血压以及继而患肾病的风险有关。但是,甲状腺素替代疗法(TRT)可逆转这些变化。当前的研究对4235名糖尿病患者进行了研究,分为两组,分别是临床甲状腺功能减退/经TRT治疗的糖尿病患者和未患有甲状腺疾病或未被诊断的糖尿病患者。比较了两组的BMI,血压,肌酐,尿微量白蛋白和尿蛋白现货水平。研究发现表明,对于甲状腺功能减退的患者,BMI较高(32.2±7.44对29.4±5.7; p <0.0001),血清肌酐水平较低(0.75±0.27对1.0±0.74; p = 0.001),收缩压较低。侧面(123.7±15.9对128.13±16.8; p = 0.015);现货尿微量白蛋白在下侧(52.58±71.65; vs. 87.77±140.86; p = 0.010),现货尿蛋白水平较低(25.3±38.3 vs 44.28±123.58; p <0.0001)。当前的研究还表明,Pearson的x2值和甲状腺功能减退的赔率/保护赔率(在TRT上)与肥胖密切相关(p <0.0001;赔率比2.28,95%CI 1.47至3.56)。但是,他们受到了HTN(p = 0.272;保护比值比1.28,95%CI 0.824至1.98),肾病(p = 0.386;保护比值1.36,95%CI 0.861至2.14)和慢性肾脏疾病(p = 0.112)的保护;保护赔率3.42,95%CI 0.83至14.13)。总之,TRT本身对心血管和肾脏系统具有保护作用。因此,在糖尿病患者中进行甲状腺筛查对于检测亚临床或临床甲状腺功能减退至关重要。

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