Functionalization of chitosan via single electron transfer living radical polymerization in an ionic liquid and its antimicrobial activity

摘要

In this work, single electron transfer living radical polymerization (SET-LRP) was used to functionalize chitosan in a well-controlled manner. The chitosan-based macroinitiator was first synthesized and then initiated the SET-LRP of methacryloyloxyethyl trimethylammonium chloride (DMC) in ionic liquid system, using Cu-0/N,N,N,N,N-pentamethyldiethylenetriamine as a catalyst. The grafting of PDMC brushes on chitosan was confirmed and analyzed by Fourier transform infrared spectroscopy and H-1 nuclear magnetic resonance. Transmission electron microscopy reveals that the chitosan copolymer showed self-assembled behavior in acetone. Surface properties of the copolymer have been investigated by environment scanning electron microscopy analysis. The linear relationship between the ln([M](0)/[M](t)) and time, the linear increase of number-average molecular mass with conversion as well as the low polydispersity index of the polymer confirmed the living/controlled features of the polymerization of DMC through SET-LRP. Finally, the chitosan copolymer demonstrates its potential antibacterial application, showing excellent inhibitive capability against Escherichia coli. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42754.