Fabrication of patterned PDLLA/PCL composite scaffold by electrospinning

摘要

Fabricating fibrous electrospun scaffolds with controllable fiber-arrangement have gained an increasing attention in the field of tissue engineering. In this study, the composite patterned D,L-poly(lactic acid)/poly(ε-caprolactone) (PDLLA/PCL) scaffolds were fabricated via electrospinning for the first time, and the order degree and contractibility of patterned composite scaffolds with different PDLLA/PCL ratios were further investigated. The results showed that the order degree of the pattern and in vitro shrinkage behaviors of PDLLA/PCL electrospun mats could be finely tuned by controlling blending ratios. The PDLLA/PCL electrospun mats with the ratio 50/50 showed the most balanced properties with controllable pattern structure and appropriate dimensional stability, and they might be a suitable candidate for tissue engineering application.