Anti-Thrombogenicity of Styrene-Butadiene-StyreneTriblock Copolymer Grafted with Poly(ethylene glycol)s

摘要

We transformed hydrophobic/hydrophobicstyrene/butadiene/styrene tri-block copolymer (SBS) tohydrophobic / hydrophilic microphase-separated surfacesby grafting with hydrophilic poly(ethylene glycol) (PEG)on poly(butadiene) (PB) domain via hydrocarboxylationand hydrobromination and investigated the anti-thrombo-genicity of these surfaces. In the case of SBS cast film fromtoluene solution, PEG was densely grafted because of thedevelopment of an unevenness on the order of several 10nm on the surface, which had a huge surface area in com-parison with poly(butadiene) rubber with its uniformlysmooth surface. Grafted PEG (molecular weight = 600)was found to clearly inhibit adhesion and activation of