Verbenone Structural Analogues Isolated from Artemesia aucheri as Natural Acarlcides against Dermatophagoides spp. and Tyrophagus putrescentiae

摘要

The acaricidal activities of Artemisia aucheri oil and (lS)-(-)-verbenone structural analogues were evaluated using a lumigant method against Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Tyrophagus putrescentiae and then compared to those of benzyl benzoate. On the basis of the LD_(50) values against D. farinae, (lS)-(-)-verbenone (1.38 μg/cm~2) was about 7.4 times more active than benzyl benzoate (10.15 μg/cm~2), followed by (+)-trans-myrtanol (2.27 μg/cm~2), (-)-trans-myrtanol (2.30 μg/cm~2), and A. aucheri oil (8.75 μg/cm~2). (lS)-(-)-Verbenone (1.25 μg/cm~2) was approximately 7.8 times more effective against D. pteronyssinus than benzyl benzoate (9.80 μg/cm~2), followed by (+)-trans-myrtanol (2.18 μg/cm~2), (-)-trans-myrtanol (2.22 μg/cm~2), and A. aucheri oil (8.46 μg/cm~2). In the case of T. putrescentiae, (1S)-(-)-verbenone (3.75 μg/cm~2) was roughly 3.5 times more toxic than benzyl benzoate (13.25 μg/cm~2), followed by (+)-trans-myrtanol (12.57 μg/cm~2), (-)-trans-myrtanol (12,95 μg/cm~2), and A aucheri oil (11.55 μg/cm~2). These results indicate that A. aucheri oil and (1S)-(-)-verbenone structural analogues may be eifective natural agents to control house dust and storage mites.