Zirconium-catalyzed intermolecular hydrophosphination using a chiral, air-stable primary phosphine

摘要

Catalytic hydrophosphination of alkenes using a chiral, air-stable primary phosphine, (R)-[2'-methoxy(1,1'-binapthalen)-2-yl]phosphine, (R)-MeO-MOPH2, proceeds under mild conditions with a zirconium catalyst, [kappa(5)-N,N,N,N,C-(Me3SiNCH2CH2)(2)NCH2CH2NSiMe2-CH] Zr (1), to selectively furnish anti-Markovnikov, air-stable secondary phosphines or tertiary phosphines with slight modification of the protocol. An intermediate in the catalysis, [(N3N)Zr(R)MeO-MOPH] (4), was structurally characterized.