A randomized, double-blind trial to evaluate immunogenicity and safety of 13-valent pneumococcal conjugate vaccine given concomitantly with trivalent influenza vaccine in adults aged = 65 years

摘要

This randomized, double-blind study evaluated concomitant administration of 13-valent pneumococcal conjugate vaccine (PCV13) and trivalent inactivated influenza vaccine (TIV) in adults aged >= 65 years who were naive to 23-valent pneumococcal polysaccharide vaccine. Patients (N = 1160) were randomized 1:1 to receive PCV13 + TIV followed by placebo, or Placebo + TIV followed by PCV13 at 0 and 1 months, with blood draws at 0, 1, and 2 months. Slightly lower pneumococcal serotype-specific anticapsular polysaccharide immunoglobulin G geometric mean concentrations were observed with PCV13 + TIV relative to PCV13. Concomitant PCV13 + TIV demonstrates acceptable immunogenicity and safety compared with either agent given alone