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SSRI ANTI-DEPRESSANTS PLAY A ROLE IN THE BRAIN'S CONNECTIVITY, SUGGESTS STUDY

机译:SSRI抗抑郁药在大脑的连通性中发挥作用,建议研究

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摘要

Selective serotonin reuptake inhibitors (SSRIs) are known to reduce intrinsic functional connectivity in brain regions implicated in mood regulation, but the full impact of SSRIs in the human brain is unclear. Research in Current Biology (online, 18 September 2014) reveals that 22 healthy volunteers given a single oral dose of the SSRI escitalopram exhibited an "acute and widespread" decrease in functional connectivity across the whole brain. Interestingly, connectivity decreased in most cortical and subcortical areas but showed a localised increase in the cerebellum and thalamus.
机译:众所周知,选择性5-羟色胺再摄取抑制剂(SSRI)可以减少与情绪调节有关的大脑区域的内在功能连通性,但尚不清楚SSRI对人脑的全面影响。 《当前生物学研究》(在线,2014年9月18日)显示,单次口服SSRI艾司西酞普兰的22名健康志愿者表现出整个大脑功能连接的“急性和广泛性”下降。有趣的是,在大多数皮质和皮质下区域,连接性下降,但小脑和丘脑局部升高。

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