Baclofen — from standard treatment for spasticity to managing alcoholism

摘要

FOR the estimated 12 million people worldwide who live with spasticity, the gamma amino butyric acid (GABA) analogue baclofen (Lioresal) has been a valuable option for relieving disabling and distressing symptoms for nearly 50 years.' Before its introduction in the UK in 1966, patients seeking relief from muscle spasms were faced with increasing lower limb weakness and impaired bladder function associated intrathecal phenol or unacceptable drowsiness with chlordiazepoxide or diazepam in the doses required.'