Prophylactic antibiotics to reduce pneumonia after acute stroke

摘要

The STROKE-INF trial (Nov 7, P1835) reported outcomes that were different from those initially included in the ISRCTN registry (number ISRCTN37118456). There were two pre-specified primary outcomes, of which one was reported in the Article, and the other ("total hospital costs") was not reported anywhere in the paper. In addition, the Article reported a new co-primary outcome ("physician diagnosed post-stroke pneumonia") that was not pre-specified, without declaring it as such. Of the 14 pre-specified secondary outcomes, six were reported in the paper, and eight were unreported anywhere in the paper. Additionally, the Article reported five new secondary outcomes that were not pre-specified, without declaring them as such.