Early identification and management of disease risk is essential to sustain health and quality of life. Several algorithms have been developed to calculate an individual's risk of coronary heart disease, including the Framingham and the Reynolds risk scores, but these have restricted use in identification of risk for both men and women. Sex-specific determination of risk is crucial in view of the validated sexual dimorphism in incidence, age of onset, progression, treatment efficacy, and morbidity and mortality for coronary artery disease.
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