The Lancet's paper of the year 2010

摘要

Between Jan 18 and Jan 31, Lancet readers voted for the research paper published in 2010 that they felt was most likely to influence practice and research. Two randomised trials led the field. Mark Loeb and colleagues' (figure) study of the effect of influenza vaccination in children on community infection rates won with 38% of the vote. A close second, with 35% of the vote, was a study (CAPRISA 004) of the effectiveness of tenofovir gel to prevent HIV infection in women. Loeb and co-authors' study was published by JAMA in March, 2010, when the influenza A H1N1 pandemic was still ongoing and the question was being asked about how to maximise the effectiveness of vaccination strategies. Observational work had suggested that vaccinating children could provide community protection. With Hutterite religious colonies as the unit of randomisation, nearly 1000 children aged 3-15 years were vaccinated against seasonal influenza or against hepatitis A. In those who were not immunised, 39 individuals (3.1%) in the influenza-vaccinated communities developed laboratory-confirmed influenza, compared with 80 (7.6%) in the communities whose children received hepatitis A vaccine.