Efficacy and safety of the weight-loss drug rimonabant.

摘要

Several points are not sufficiently highlighted by Robin Christensen and colleagues in their meta-analysis of rimonabanttrials.At present, rimonabant is the most efficacious weight-lowering agent available. It is not simply an appetite-suppressant and weight-loss agent. A substantial part of its beneficial metabolic effects on glycosylated haemoglobin (HbA_(1c), HDLcholesterol, and triglycerides is independent of its weight-lowering properties. The significance of these effects has been recognised by the European regulatory authority, and the effect of rimonabant on improving HbA_(1c) concentrations in patients with type 2 diabetes has been emphasised in an updated summary of product characteristics.