Jean-Louis Frossard and colleagues (Jan 12, p 143) state intheir Seminar on acute pancreatitis that "when infection is suspected and fine-needle aspiration of the pancreas for bacteriology done, the accepted treatment is to start antibiotics, intravenous imipenem or meropenem, for 14 days". This advice comes from a literature review that included a small trial comparing imipenem with pefloxacin which found less infected necrosis in the imipenem group, but a non-significant difference in mortality, and a head-to-head trial of imipenem versus meropenem, which showed them to be equally efficacious.
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