Combination antifungal therapy for cryptococcal meningitis

摘要

In the trial of combination'therapy for cryptococcal meningitis in patients with human immunodeficiency virus infection, Day et al. (April 4 issue)1 found a survival benefit associated with 2 weeks of therapy with amphoter-icin B and flucytosine as compared with ampho-tericin B monotherapy. The results of this trial reinforce the treatment combination as the standard per current guidelines.2-3 In locations where amphotericin B therapy is not feasible, flucytosine is recommended in combination with flu-conazole.2"4 However, the availability of flucytosine worldwide remains grossly inadequate.