The Impact of PBRM1 Expression as a Prognostic and Predictive Marker in Metastatic Renal Cell Carcinoma

摘要

Purpose: PBRM1, a SWI/SNF chromatin remodeling complex gene, is the second most frequently mutated gene in clear cell renal cell carcinoma. Although previous studies showed that loss of PBRM1 expression was associated with poor prognosis of renal cell carcinoma, these studies were performed on earlier stage, surgically resected renal cell carcinoma. Accordingly we investigated the PBRM1 expression profile in patients with stage IV renal cell carcinoma to determine the prognostic and predictive value of PBRM1.