This month in investigative urology.

摘要

Cytogenetic Aberrations in Infertile Men:Infertility is a major health problem of multifactorial etiology that involves males and females, and affects nearly 6 million couples in the United States. The causes of male infertility are heterogeneous but more than 50% of cases have a genetic basis. Since specific genetic defects have been identified in less than 20% of infertile males, the majority of causes remain to be elucidated. The most common cytogenetic defects associated with nonobstructive azoospermia are numerical and structural chromosome abnormalities, including Klinefelter syndrome (47,XXY) and Y chromosome microdeletions. Yatsenko et al (page 1636) from Houston, Texas reviewed the cytogenetic results in 668 infertile men with oligozoospermia and azoospermia referred for routine cytogenetic analysis between January 2004 and March 2009. High resolution Giemsa banding chromosome analysis and/or fluorescence in situ hvbridization was performed.