Asymmetric Syntheses of Medicinally Important Isoindolinones (S)-PD 172938, (R)-JM 1232, and Related

Suneja Arun; Bisai Vishnumaya; Singh Vinod K.

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Asymmetric Syntheses of Medicinally Important Isoindolinones (S)-PD 172938, (R)-JM 1232, and Related

机译：药用重要的异吲哚啉酮（S）-PD 172938，（R）-JM 1232和相关药物的不对称合成

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A unified approach for the asymmetric syntheses of medicinally important isoindolinones (S)-PD 172938 and (R)-JM 1232 has been accomplished via a Cu(I)-PYBOX-diPh catalyzed highly enantioselective (up to 99% ee) alkynylation/lactamization sequence in a one-pot fashion. The overall sequence involves one C-C and two C-N bond forming events in one pot starting from inexpensive starting material in ambient reaction conditions.

机译：医学上重要的异吲哚啉酮（S）-PD 172938和（R）-JM 1232的不对称合成的统一方法已通过Cu（I）-PYBOX-diPh催化的高度对映选择性（ee高达99％）炔基化/内酰胺化反应完成以一锅法的顺序排列。在环境反应条件下，从廉价的起始原料开始，整个过程包括在一锅中一次C-C和两次C-N键形成事件。

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《The Journal of Organic Chemistry》 |2016年第11期|共10页
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Suneja Arun; Bisai Vishnumaya; Singh Vinod K.;
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1. Asymmetric Syntheses of Medicinally Important Isoindolinones (S)-PD 172938, (R)-JM 1232, and Related [J] . Suneja Arun, Bisai Vishnumaya, Singh Vinod K. The Journal of Organic Chemistry . 2016,第11期

机译：药用重要的异吲哚啉酮（S）-PD 172938，（R）-JM 1232和相关药物的不对称合成
2. A General Catalytic Route to Enantioenriched Isoindolinones and Phthalides: Application in the Synthesis of (S)-PD 172938 [J] . Ray Sumit K., Sadhu Milon M., Biswas Rayhan G., Organic letters . 2019,第2期

机译：对苯丙胺异吲哚酮和邻苯二甲酸盐的一般催化途径：在合成（S）-PD 172938中的应用
3. The effects of topical and intravenous JM-1232(-) on cerebral pial microvessels of rabbits [J] . Kodai Ikemoto, Tadahiko Ishiyama, Noriyuki Shintani, BMC Anesthesiology . 2015,第1期

机译：局部和静脉内JM-1232（-）对家兔脑膜微血管的影响
4. (1232.pdf) EDUCATION, INNOVATION AND RESEARCH: A PERPETUAL DREAM INTO ITS REALIZATION IN THE KINGDOM OF BAHRAIN [C] . M Alseddiqi, Yogesh Anchan International Technology, Education and Development Conference . 2013

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5. I. A1,3- strain enabled retention of chirality during Bis-cyclization of β-ketoamides: Asymmetric synthesis and bioactivity of salinosporamide a and derivatives II. Optimization of an Organic syntheses procedure: asymmetric nucleophile-catalyzed aldol-lactonization with aldehyde acids [D] . Nguyen, Henry 2010

机译：I. A1,3-菌株能够在β-酮基酰胺的双环化过程中保留手性：salinosporamide a和衍生物II的不对称合成和生物活性。有机合成程序的优化：醛酸不对称亲核催化醛醇内酯化
6. JM-1232(−) and propofol a new combination of hypnotics with short-acting andnon-cumulative preferable properties [O] . Saori Taharabaru, Takahiro Tamura, Michiko Higashi, 2021

机译：JM-1232（ - ）和异丙酚一种新的催眠药组合短作用和非累积优选性能
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Asymmetric Syntheses of Medicinally Important Isoindolinones (S)-PD 172938, (R)-JM 1232, and Related

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