One-Pot Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolines and Isoquinolino[3,4-b]quinoxalines via Tandem Cyclization Strategies

摘要

Two operationally simple one-pot protocols have been developed for the synthesis of amino-functionalized benzo [4,5] imidazo [2,1-a]isoquinolines and isoquinolino [3,4-b]quinoxalines. Optimization data and substrate scope for these atom-economical transformations, which engage commercially available o-phenylenediamines and o-cyanobenzaldehydes, are discussed.