Enantioselective Formal Synthesis of Nectrisine Using a Palladium Catalyzed Asymmetric Allylic Amination and Cross-Metathesis as Key Steps

摘要

A formal enantioselective synthesis of nectrisine, a potent alpha-glucosidase inhibitor, was carried out starting from butadiene monoepoxide through a synthetic sequence involving enantioselective allylic substitution, cross-metathesis, dihydroxylation, and cyclization.