Protecting-Group-Free Total Synthesis of Aplykurodinone-1

摘要

A concise, stereoselective, and protecting-group-free total synthesis of aplykurodinone-1 from HajosParrish ketone was described. The synthetic approach features a sequence of aerobic allylic oxidation and elimination of alcohol 9. The key intermediate for this synthesis was formed by a stereoselective intramolecular radical cyclization.