Identifying Selective Host-Guest Interactions Based on Hydrogen Bond Donor-Acceptor Pattern in Functionalized AI-MIL-53 Metal-Organic Frameworks

摘要

We present a study analyzing the selectivity of host—guest interactions in a series of functionalized Al-MIL-53-X metal-organic frameworks with X = H, NH2, and NHCHO using acetone, ethanol, and water as probe molecules. While the amino group introduces additional hydrogen bond donor centers the NHCHO anchors function as donor and acceptor. The guests were chosen due to their ability to act solely as an acceptor in the case of acetone, whereas ethanol and water provide acceptor and donor qualities with a gradual decrease of the acceptor strength toward ethanol. The characterization of the host—guest interactions includes a comprehensive solid-state NMR spectroscopic study based on a full assignment of ~1H and ~(13)C high-resolution spectra using CRAMPS decoupling schemes to enhance ~1H resolution combined with advanced 2D HETCOR (~1H-~(13)C, ~1H-~(27)A1, and ~1H-~(14)N) spectra at high magnetic fields. In spite of a pronounced dynamical disorder of the guests, we could identify a preferred binding of the acetone via a NH-OC hydrogen bond for the NH2 and the NHCHO anchor groups by analyzing trends in the ~(13)C isotropic chemical shifts. At the same time ~1H—~1H through-space connectivities reveal a close vicinity of the acetone methyl groups to the benzene rings, of the linkers. In contrast, for ethanol and water, the interaction with the anchor groups is too weak to compete with the thermal disorder at room temperature.