Erratum: Cathepsin K is involved in development of psoriasis-like skin lesions through TLR-dependent Th17 activation (Journal of Immunology (2013) 190 (4805-4811))

摘要

Cathepsin K is involved in development of psoriasis-like skin lesions through TLR-dependent Thl7 activation. J. Immunol. 190: 4805-4811 There was an error in the data of Fig. 5 as published. Data shown in Fig. 5A as 1112a gene expression was duplicated from the data for 1123a. The correct data for 1112a gene expression is now shown in the revised Fig. 5 below. The figure legend was correct as published and is shown below for reference. This error does not change the conclusion of the paper.FIGURE 5. Effect of NC-2300 on IL-12 and IL-23 in bone marrow-derived mDCs after treatment of TLR7/8 ligands. (A) The mDCs were pretreated with vehicle alone or 10 |xM NC-2300 for 3 h prior to stimulation with 10 nM R848 for 24 h at 37°C. Treatment of R848-induced transcripts of III2a, III2b. and 1123a, all of which were inhibited by pretreatment with NC-2300. The data are shown as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001, n = 6. Tukey test. (B) R848 was replaced with imiquimod (IMQ, 10 |xM) under the same experimental protocol. The results were mostly reproduced when IMQ was used. The data are shown as mean ± SD, **p < 0.01, ***p < 0.001, n = 6. Tukey test. (C) The mDCs were pretreated with vehicle alone or 1, 10, and 30 jjlM NC-2300 for 3 h prior to stimulation with 10 muM IMQ for 24 h at 37°C. The data represent mean ± SD, ###p < 0.001 versus vehicle-treated mDCs; *p < 0.05, **p < 0.01 versus IMQ-treated mDCs, n = 5. Tukey test.