Comment on 'innate immune collectin surfactant protein d simultaneously binds both neutrophil extracellular traps and carbohydrate ligands and promotes bacterial trapping'.

摘要

Interestingly, Malawista et al. (10) of Yale University conducted a series of studies in the 1980s and showed that enucleated neutrophils "survive" and "phagocytose" microbes. It would be useful to consider these observations in the context of NETosis. Neutrophils have been considered to release soluble proteases, which eventually cause excess tissue inflammation and injury. Recent data show that NETosis also releases "soluble" NET components (2, 4, 5). During NETosis, neutrophil proteases are attached to the chromatin scaffold of the NETs; hence, NETs could be advantageous for the host under physiological conditions. During pathological states, accumulation of excessive NET components including DNA and proteases could be harmful to the tissues [e.g., airways of patients with cystic fibrosis (4)]. Although clearance of NETs has not been systematically studied, DNAse enzyme has been suggested to destroy the NETs (8, 11).