Cutting Edge: Dendritic Cells Copulsed with Microbial anc Helminth Antigens Undergo Modified Maturation,Segregate the Antigens to Distinct Intracellular Compartments,and Concurrently Induce Microbe-Specific Th1 and Helminth-Specific Th2 Responses

摘要

To examine the ability of dendritic cells (DC) to discriminate between helminth and microbialAg and induce appropriately polarized Th responses,mouse DC were copulsed with the helminth Ag,schistosome egg Ag (SEA),along with the bacterium Proprionebacterium acnes,Pa,and transferred into wild-type mice.Strikingly,SEA/Pa-co-pulsed DC induced concurrent Pa-specific Thl (but not Th2) responses and SEA-specific Th2 (but not Thl) responses.Although DC exposed to bothAg undergo many of the maturation-associated changes that accompany exposure to Pa alone,Pa-inducedIL-12production was inhibited by SEA.Examination ofAg uptake revealed that SEA and Pa are acquired via discrete pathways and enter non-overlapping intracellular compartments.Data suggest that segregation of SEA and Pa into distinct compartments,coupled with SEA-induced modifications of the DC maturation pathway,are significant components of the ability of DC to interpret signals inherent to SEA and Pa and induce appropriately polarized Th responses.