A convenient method for synthesis of polyfunctional dihydropyrrole spiro-fused oxindole-2-ones via an organocatalytic tandem Michael/cyclization sequence

摘要

A new methodology was developed for the synthesis of spirocyclic oxindoles bearing polyfunctional dihydropyrrole units via an organocatalytic tandem Michaelicyclization sequence. Products bearing adjacent quaternary-tertiary stereocenters were smoothly obtained in high yields (up to 97% yield) with excellent diastereoselectivities up to >20/1. (C) 2014 Elsevier Ltd. All rights reserved.