Imidazolidinone based chiral auxiliary mediated acetate aldol reactions of isatin derivatives and stereoselective synthesis of 3-substituted-3-hydroxy-2-oxindoles

摘要

Acetate aldol reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one chiral auxiliary have been optimized with high yields and diastereoselectivity on various N-substituted isatins. The standardized reaction condition was employed for the stereoselective synthesis of furoindolines, and the pyrroloindole based natural products flustraminol B and N-benzyl alline. (C) 2015 Elsevier Ltd. All rights reserved.