Synthesis of 3-benzazepines and azepino[4,5-b]heterocyclic ring systems via intramolecular Friedel-Crafts cyclization

Robert B. Kargbo; Zohreh Sajjadi-Hashemi; Sujata Roy

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Synthesis of 3-benzazepines and azepino[4,5-b]heterocyclic ring systems via intramolecular Friedel-Crafts cyclization

机译：分子内Friedel-Crafts环化反应合成3-苯并ze庚因和azepino [4,5-b]杂环系统

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The intramolecular Friedel-Crafts cyclization was found to be effective for the synthesis of 3-benzazepines and azepino[4,5-b]heterocyclic ring systems using simple allylic bromides tethered to activated aromatic nuclei. Amongst the various Lewis acids screened, Bi(OTf)3 was found to be the most effective 'ecofriendly' catalyst for the cyclization.

机译：发现分子内的Friedel-Crafts环化可有效地使用简单的烯丙基溴束缚到活化的芳香核来合成3-苯并ze庚因和azepino [4,5-b]杂环系统。在筛选的各种路易斯酸中，发现Bi（OTf）3是最有效的环化“生态友好型”催化剂。

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《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |2013年第15期|共4页
作者
Robert B. Kargbo; Zohreh Sajjadi-Hashemi; Sujata Roy;
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正文语种 eng
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Friedel-Crafts cyclization; 3-Benzazepines; Allylic bromides; Activated aromatic nuclei;

机译：Friedel-Crafts环化;3-苯并ze庚因;烯丙基溴;活化的芳核;

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1. Synthesis of 3-benzazepines and azepino[4,5-b]heterocyclic ring systems via intramolecular Friedel-Crafts cyclization [J] . Robert B. Kargbo, Zohreh Sajjadi-Hashemi, Sujata Roy Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2013,第15期

机译：分子内Friedel-Crafts环化反应合成3-苯并ze庚因和azepino [4,5-b]杂环系统
2. Synthesis of Azepino[4,5-b]indolones by an Intramolecular Cyclization of Unsaturated Tryptamides [J] . Nidhiry John Eugene, Prasad Kavirayani R. Synlett . 2014,第18期

机译：不饱和类胰酰胺的分子内环化反应合成叠氮[4,5-b]吲哚酮
3. SYNTHESIS OF THE NEW (CYCLOPENTA[B]PYRROLO[1,2-D])AZEPINO[4,5-B]INDOLE RING SYSTEM [J] . Noe E., Zhang QA., Djate F., Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 1996,第32期

机译：新型（环戊二烯[B]吡咯[1,2-D]）阿哌丁[4,5-B]吲哚环的合成
4. Silaindene-Containing New pi-Electron Systems:Efficient Synthesis Based on the Intramolecular Reductive Cyclization and the Silicon Effects on Their Photophysical Properties [C] . Caihong Xu, Atsushi Wakamiya, Shigehiro Yamaguchi Symposium on Organometallic Chemistry . 2004

机译：含有硅烷二烯的新型PI-Electron系统：基于分子内还原环化和硅效应对其光学性质的高效合成
5. Synthetic applications of the type 2 intramolecular Diels-Alder reaction: (1) Efforts toward the total synthesis of the welwitindolinone alkaloids and (2) Enantioselective synthesis of bridged bicyclic ring systems. [D] . Brailsford, John A. 2009

机译：2型分子内Diels-Alder反应的合成应用：（1）努力实现welwitindolinone生物碱的全合成，以及（2）桥联双环系统的对映选择性合成。
6. Remarkably Mild and Efficient Intramolecular Friedel-Crafts Cyclization Catalyzed by In(III) [O] . Ryuji Hayashi, Gregory R. Cook -1

机译：In（III）催化的温和高效的分子内Friedel-Crafts环化反应
7. Synthesis of Fused 4,5-Disubstituted Indole Ring Systems by Intramolecular Friedel-Crafts Acylation of 4-Substituted Indoles [O] . -1

机译：通过分子内的Friedel-Crafts的4-取代吲哚酰化合成融合的4,5-二取代的吲哚环系统

Synthesis of 3-benzazepines and azepino[4,5-b]heterocyclic ring systems via intramolecular Friedel-Crafts cyclization

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