Organocatalytic aldol reaction of indole-3-carbaldehydes with ketones: synthesis of chiral 3-substituted indoles

摘要

An efficient aldol reaction of indole-3-carbaldehydes with ketones is described. O-TBS-protected L-threonine promoted the aldol addition of ketones to indole-3-carbaldehydes affording 3-indolylmethanols with good to excellent yields and diastereoselectivities, and excellent enantioselectivities.