Complementary α-alkylatioe approaches for a sterically hindered spiro[pyrazolopyranpiperidine]ketoee

摘要

Complementary α-alkylation methods are used to derivatize a sterically hindered spiro[pyrazolopyranpi-peridine]ketone. More specifically, enolate alkylations in the presence of DMPU and aldol condensations are employed to deliver these compounds.