Stereoselective synthesis of tetrahydro-2H-[2]benzopyrano[3,4-c]pyrrol-3-ones and related compounds as precursors of serotonin 5-HT_(2C) receptor agonists

Stuart Francis; Takao Kiyoi; Mark Reid

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Stereoselective synthesis of tetrahydro-2H-[2]benzopyrano[3,4-c]pyrrol-3-ones and related compounds as precursors of serotonin 5-HT_(2C) receptor agonists

机译：立体选择性合成四氢-2H- [2]苯并吡喃并[3,4-c]吡咯-3-酮和相关化合物作为5-羟色胺5-HT_（2C）受体激动剂的前体

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Tetrahydro-2H-[2]benzopyrano[3,4-c]pyrroI-3-ones and the related 3a-methyl-2,3.3a,4,5,9b-hexahydro-1H-benzo[e]isoindole analogues were synthesised by an intramolecular Diels-Alder reaction. The observed stereoselectivity was dependent upon the nature of the tethered dienophile as well as the judicious placement of the amide.

机译：合成了四氢-2H- [2]苯并吡喃并[3,4-c]吡咯I-3-酮和相关的3a-甲基-2,3.3a，4,5,9b-六氢-1H-苯并[e]异吲哚类似物通过分子内Diels-Alder反应。观察到的立体选择性取决于束缚的双亲物的性质以及酰胺的明智位置。

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《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |2011年第27期|共5页
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Stuart Francis; Takao Kiyoi; Mark Reid;
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1. Stereoselective synthesis of tetrahydro-2H-[2]benzopyrano[3,4-c]pyrrol-3-ones and related compounds as precursors of serotonin 5-HT_(2C) receptor agonists [J] . Stuart Francis, Takao Kiyoi, Mark Reid Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2011,第27期

机译：立体选择性合成四氢-2H- [2]苯并吡喃并[3,4-c]吡咯-3-酮和相关化合物作为5-羟色胺5-HT_（2C）受体激动剂的前体
2. Synthesis of hexahydro[2]benzopyrano[3,4-c]pyrroles as serotonin 5-HT_(2C) receptor agonists via intramolecular hetero Diels-Alder reactions [J] . Takao Kiyoi, Mark Reid, Stuart Francis Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2011,第27期

机译：分子内杂Diels-Alder反应合成5-羟色胺5-HT_（2C）受体激动剂六氢[2]苯并吡喃并[3,4-c]吡咯
3. Synthesis of hexahydro[2]benzopyrano[4,3-c]pyridines as serotonin 5-HT_(2C) receptor agonists via intramolecular hetero Diels-Alder reactions [J] . Yasuko Kiyoi, Steven Laats, Takao Kiyoi Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2011,第27期

机译：分子内杂Diels-Alder反应合成5-羟色胺5-HT_（2C）受体激动剂六氢[2]苯并吡喃并[4,3-c]吡啶
4. Dipeptide Tyr-Leu Exhibits Anxiolytic-like Activity after Oral Administration via Activating Serotonin 5-HT_(1A),Dopamine D1 and GABA_A Receptors [C] . Norimasa Kanegawa, Chihiro Suzuki, Kousaku Ohinata Japanese peptide symposium . 2010

机译：二肽Tyr-Leu通过激活血清素5-HT_（1A），多巴胺D1和GABA_A受体，在口服给药后表现出抗焦力样活性
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6. We Need 2C but Not 2B: Developing Serotonin 2C (5-HT2C) Receptor Agonists for the Treatment of CNS Disorders [O] . Dr. Jianjun Cheng, Prof. Alan P. Kozikowski -1

机译：我们需要2C但不需要2B：开发用于治疗中枢神经系统疾病的5-羟色胺2C（5-HT2C）受体激动剂
7. Altered 5-HT_2Creceptor agonist-induced responses and 5-HT_2Creceptor RNA editing in the amygdala of serotonin transporter knockout mice [O] . Wendland Jens R, French Helen T, Laporte Justin L, 2011

机译：5-HT _{2C 受体激动剂诱导的反应和5-HT _{2C 受体RNA在血清素转运蛋白敲除小鼠杏仁核中的编辑}}

Stereoselective synthesis of tetrahydro-2H-[2]benzopyrano[3,4-c]pyrrol-3-ones and related compounds as precursors of serotonin 5-HT_(2C) receptor agonists

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