Palladium-catalyzed cross-coupling of aryl chlorides with alkenylboronic acids with low E/Z isomerization

摘要

Using a bulky electron-rich monodentate benzoferrocenyl phosphine as supporting ligand,an efficient protocol for stereoselective palladium-catalyzed Suzuki-Miyaura cross-coupling of aryl chlorides with alkenylboronic acids was uncovered.Using this protocol,both trans-and cis-alkenylboronic acids can be coupled with high stereoselectivity giving the corresponding vinylarenes in good to quantitative yields.Electron-poor and-rich aryl chlorides including highly hindered ones are all suitable substrates for the reaction.