Extended peptoids:a new class of oligomers based on aromatic building blocks

摘要

Peptoids (N-substituted polyglycines) represent a class of bioinspired oligomers that have unique physical and structural properties.Here,we report the construction of 'extended peptoids' based on aromatic building blocks,in which the N-alkylamino-acetyl group of the peptoid backbone has been replaced by an N-alkylaminomethylbenzoyl spacer.Both meta- and para-bromo-methylbenzoic acids were synthesized,providing access to a new class of peptoids.Further,inclusion of hydrophilic side chains confers water solubility to these compounds,showing that,like simple peptoids,extended peptoids add an extra dimension to synthetic poly-amide oligomers with potential application in a variety of biological contexts.