Biginelli reaction in aqueous medium:a greener and sustainable approach to substituted 3,4-dihydropyrimidin-2(1H)-ones

摘要

An environmentally benign aqueous Biginelli protocol for the synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones using polystyrenesulfonic acid (PSSA) as a catalyst has been achieved.These microwave-assisted reactions proceed efficiently in water in the absence of organic solvent,with simple filtration as the product isolation step.