Mono-nitration of aromatic compounds via their nitric acid salts

摘要

Aromatic compounds bearing a basic nitrogen atom can be converted to the corresponding nitric acid salts.Mono-nitration of the compounds can be carried out by adding a dichloromethane solution of the salts to sulfuric acid,or by adding acetyl chloride(or trifluoroacetic anhydride)to a dichloromethane solution of the salts.This protocol provides,among other benefits,the most convenient and reliable way for the prevention of over-/under-nitration and is especially suitable for scale-up.