A new asymmetric synthesis of the natural enantiomer of the indolizidino[8,7-b]indole alkaloid (+)-harmicine

摘要

We report a novel,facile and asymmetric approach for the synthesis of the indole alkaloid (+)-harmicine via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step,and verify the relative stereochemistry of the key synthetic intermediate in this approach through X-ray crystallography.