Total syntheses of (±)-alpha-acorenol,p-acorenol,alpha-epi-acorenol and beta-epi-acorenol via an Ireland ester Claisen rearrangement and RCM reaction sequence

摘要

Total syntheses of (±)-alpha-and beta-acorenols and (±)-alpha-and beta-epi-acorenols,spiro[4.5]decane sesquiterpenes,isolated from the western Australian sandalwood oil,have been accomplished employing a combination of Ireland ester Claisen rearrangement and RCM reactions for an efficient construction of the spiro[4.5]decane present in acoranes.