Synthesis of the JK/LM-ring model of prymnesins, potent hemolytic and ichthyotoxic polycyclic ethers isolated from the red tide alga Prymnesium parvum: confirmation of the relative configuration of the K/L-ring juncture

摘要

Synthesis of the JK/LM-ring model of prymnesins, polycyclic ether toxins isolated from the red tide phytoflagellate, Pryninesilun parvian, is described. Comparison of the H-1 and C-13 NMR data of the synthetic model with those reported for prymnesins confirmed the reported configurational assignment of the K/L-ring juncture. (c) 2006 Elsevier Ltd. All rights reserved.