Synthesis and stereochemical confirmation of the HI/JK ring system of prymnesins, potent hemolytic and ichthyotoxic glycoside toxins isolated from the red tide alga

摘要

Stereocontrolled synthesis of the HI/JK ring model of the prymnesins, glycosidic toxins isolated from the red tide phytoflgellate Prymnesium parvum, is described. Comparison of its ~1H and ~13C NMR data with those of the natural toxins established the earlier stereochemical assignments.