Organocatalyzed asymmetric alpha-hydroxyamination of alpha-branched aldehydes:asymmetric synthesis of optically active N-protected alpha,alpha-disubstituted amino aldehydes and amino alcohols

摘要

Enantioselective direct alpha-hydroxyamination and alpha-aminoxylation of alpha-branched aldehydes using a proline-derived tetra-zole catalyst is described herein.alpha-Hydroxyamination adducts with up to 90% ee were obtained by the reaction of nitrosobenzene with unactivated alpha-branched aldehydes under mild reaction conditions.