Highly enantioselective reduction of ketones by chiral diol-modified lithium aluminum hydride reagents

摘要

Some readily available chiral diols from indene and (D)-mannitol were investigated as chiral modifiers in lithium aluminum hydride reduction of ketones, and it was discovered that further modification of these reducing reagents by a simple a-amino alcohol resulted in a remarkable increase in optical yield. Among the investigated chiral modifiers, chiral diol I gave the highest enantio selectivities. (c) 2005 Elsevier Ltd. All rights reserved.