Synthesis of new halo-containing acetylenes and their application to the synthesis of azoles

摘要

The convenient synthesis often halo- and an isoxazole-containing acetylenes from the reaction of acetylenes with n-butyl lithium and subsequent reaction with an electrophile agent (ethyl trichloroacetate,ethyl dichloroacetate,trifluoroacetic anhydride,3-methylisoxazol-5-carbonyl chloride,carbon tetrachloride and l,l,l-trifluoro-4-ethoxy-3-buten-2-one) in moderated to good yields is reported.The application of l,l,l-trichloro-4-phenyl-3-butyn-2-one on the synthesis of two azoles is also showed.