An efficient ring-closing metathesis reaction of geminally disubstituted olefins using first generation Grubbs' catalyst: enantiospecific synthesis of pacifigorgianes

摘要

An efficient ring closing metathesis reaction with first generation Grubbs' catalyst [PhCH=RuCl_2(PCy_3)_2] involving geminally disubstituted olefins has been discovered. It has been extended to the enantiospecific synthesis of pacifigorgiane sesquiterpenes.